This site uses tracking information. Visit our privacy policy. Click to agree to this policy and not see this again.

Ophthalmology and Visual Sciences

Corneal and lenticular pigmentation from long-term chlorpromazine use

Corneal and lenticular pigmentation from long-term chlorpromazine use

Category(ies): Cornea, Lens
Contributor: Zachary Q. Mortensen, MD; Ryan J. Diel, MD; A. Tim Johnson, MD
Photographer: D. Brice Critser, CRA, OCT-C

55-year-old male with history of schizophrenia and long term chlorpromazine use. There is blue-gray dyspigmentation of the nose, bilateral cheeks, forearms, dorsal hands and arms in photo-distributed areas. Slit lamp examination shows diffuse punctate corneal deposits through the posterior stroma, descemet membrane, and endothelium of the cornea.


Contributor: Elizabeth Gauger, MD
Photographer: D. Brice Critser, CRA, OCT-C

Corneal and lenticular pigmentation from long-term chlorpromazine use

59-year-old male with history of schizophrenia and long-term chlorpromazine (thorazine) treatment. His ocular exam is notable for fine pigment deposition in the posterior corneal stroma and endothelium. In addition, there is pigmentation in a stellate pattern on the anterior lens and lens capsule. This rarely causes a decrease in visual acuity.

These findings are characteristic of long-term thorazine use and are suspected to be related to dose and duration of treatment. It is recommended that persons undergoing long-term treatment with thorazine have regular eye examinations.

References:
  1. Huff, L S, Prado, R, Pederson, JF, Dunnick, CA, Lucas, LM (2014). Chlorpromazine-induced skin pigmentation with corneal and lens opacities. Cutis, 93(5), 247-250.
  2. Gupta, A., Agarwal, A., & Ram, J. (2014). Reversal of Toxic Manifestations of Chlorpromazine. JAMA ophthalmology, 132(10), 1177-1177.

Image Permissions:
Creative Commons

Ophthalmic Atlas Images by EyeRounds.org, The University of Iowa are licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.