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Ophthalmology and Visual Sciences

Granular corneal dystrophy

Granular corneal dystrophy

Category(ies): Cornea, Genetics, Inherited Eye Disease
Contributor: David Phillips, MD
Photographer: Toni Venckus, CRA

This 30-year-old Chinese female presented for evaluation of granular corneal dystrophy. She had a strong family history of cornea problems suggesting an autosomal dominant inheritance which supported the diagnosis of BIGH3 (Transforming Growth Factor Beta 1 gene, TGFβ1) related disease. Vision was 20/20 in both eyes.

gray-white breadcrumb-like opacities in the anterior cornea which is classic for granular dystrophy
Slit lamp photo, OS, demonstrate gray-white breadcrumb-like opacities in the anterior cornea, which is classic for granular dystrophy.
gray-white breadcrumb-like opacities in the anterior cornea which is classic for granular dystrophy
Slit lamp photo, OD, demonstrate gray-white breadcrumb-like opacities in the anterior cornea, which is classic for granular dystrophy.